![]() Antigens detected by flow cytometric immunophenotyping were assigned a score of 2, 1 or 0.5 depending on specificity of a particular antigen for myeloid, T lymphoid or B lymphoid lineage. MPAL or biphenotypic leukemia is defined when the score from two separate lineages is more than two. This scoring system is aimed at distinguishing cases of MPAL from those with aberrant expression i.e. The numerical scoring system for defining mixed phenotype acute leukemia (MPAL) was formulated by European Group for the the immunological classification of leukemias (EGIL). ![]() Ambiguous leukemias are rare and account for 4% of all cases of acute leukemia and frequently demonstrate an aggressive disease course with mean survival rates less than those of leukemias derived from single cell lineage.
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